李兰

    2018-09-06 11:19:10 来源:生命科学学院          浏览数:0

姓名:李兰
称:副教授

学院系所:生命科学学院

学科领域:发育生物学

联系电话:0532-88030246

电子邮件:lilan9600@126.com

通讯地址:山东省青岛市城阳区长城路700

伟德开户/生物楼C410
 

1、个人简介:

李兰,博士,副教授,硕士生导师。主要从事动物生殖毒理学的研究工作,主持国家自然科学基金、863项目子课题等4项,在《Toxicology and Applied Pharmacology》、《Theriogenology》、《Histochemistry and Cell Biology》、《Reproduction Fertility and Development》等国际刊物上发表SCI收录的研究论文50余篇,是《Journal of Proteomics》、《Reproductive Biology & Endocrinology》等10余种国际刊物的特邀审稿人。

 

2、工作经历:

2018-至今,伟德开户,副教授

2017-2017,青岛农业大学动物科技学院,高级实验师

2012-2016,青岛农业大学动物科技学院,实验师

2007-2011,青岛农业大学动物科技学院,助理实验师

2000-2005,军事医学科学院生物工程研究所,实验员

 

3、学习经历:

2012-2016,西北农林科技大学动物科技学院,博士

2005-2007,青岛农业大学动物科技学院,硕士

1996-2000,西北农林科技大学动物科技学院,学士

 

4、教学工作:

为本科生教授《动物生理学》、《动物生理学实验》、《动物繁殖学》、《动物繁殖学实验》等课程。

 

5、研究方向:

饲料霉菌毒素危害动物卵泡发育的机制及挽救技术

 

6、科研项目:
国家自然科学基金面上项目:赤霉烯酮暴露妊娠母猪影响胎儿卵母细胞发生的分子机制
国家自然科学基金青年基金:胰岛素通过Akt信号通路调节卵泡形成与发育激活的分子机制
国家863计划项目子课题:家畜卵泡诱导发育技术研究与应用

横向课题:环境类雌激素危害生殖健康的发生机制及挽救技术研究

 

7、近5年发表的论文(10篇):

Rui-Qian Zhang, Xiao-Feng Sun, Rui-Ying Wu, Shun-Feng Cheng, Guo-Liang Zhang, Qiu-Yue Zhai, Xue-Lian Liu, Yong Zhao, Wei Shen, Lan Li *. Zearalenone exposure elevated the expression of tumorigenesis genes in mouse ovarian granulosa cells. Toxicology and Applied Pharmacology, 2018, 356: 191-203.
 
Xue-Lian Liu, Rui-Ying Wu, Xiao-Feng Sun, Shun-Feng Cheng, Rui-Qian Zhang, Tian-Yu Zhang, Xi-Feng Zhang, Yong Zhao, Wei Shen, Lan Li*. Mycotoxin zearalenone exposure impairs genomic stability of swine follicular granulosa cells in vitro. International Journal of Biological Sciences, 2018 Feb 12; 14(3): 294-305.
 
Guo-Liang Zhang, Jun-Lin Song, Yi Zhou, Rui-Qian Zhang, Shun-Feng Cheng, Xiao-Feng Sun, Guo-Qing Qin , Wei Shen, Lan Li *. Differentiation of sow and mouse ovarian granulosa cells exposed to zearalenone in vitro using RNA-seq gene expression. Toxicology and Applied Pharmacology, 2018, July 1, 350: 78-90
 
Kehan Liu (#), Xiaofeng Sun (#), Yanzhong Feng, Shunfeng Cheng, Bo Li, Yapeng Li, Wei Shen, Lan Li (*). The impact of zearalenone exposure on the meiotic progression and primordial follicle assembly during early oogenesis. Toxicology and Applied Pharmacology, 2017 Aug 15; 329: 9-17.
 
Guoliang Zhang, Xiaofeng Sun, Yanzhong Feng, Bo Li, Yapeng Li, Fan Yang, Martin C Nyachoti, Wei Shen, Shiduo Sun(*), Lan Li(*). Zearalenone exposure impairs ovarian primordial follicle formation via down-regulation of Lhx8 expression in vitro. Toxicology and Applied Pharmacology, 2017 Feb 15; 317: 33-40.
 
Pengfei Zhang, Yong Zhao, Shuai Yu, Jing Liu, Yanan Hao, Hongfu Zhang, Wei Ge, Lingjiang Min, Wei Shen, Qunjie Li, Xin Kou, Huanfa Ma, Lan Li (*). Proteome analysis of egg yolk after exposure to zinc oxide nanoparticles. Theriogenology, 2017 Jun, 95: 154-162.
 
Weidong Zhang#, Yong Zhao#, Hongfu Zhang, Shukui Wang, Zhihui Hao, Jingcai Liu, Yuqing Yuan, Pengfei Zhang, Wei Shen, Lan Li (*). Alteration of gene expression by zinc oxide nanoparticles or zinc sulfate in vivo, and comparison with in vitro data-a harmonious case. Theriogenology, 2016 Aug; 86(3): 850-861.
 
Lan Li, Jingcai Liu, Fangnong Lai, Huanqi Liu, Xifeng Zhang, Paul W. Dyce, Wei Shen, Hong Chen (*), Di (2-ethylhexyl) phthalate exposure impairs growth of antral follicle in mice. PLoS One, 2016 Feb 4, 11(2): e0148350
 
Lan Li, Jingcai Liu, Yong Zhao, Fangnong Lai, Fan Yang, Wei Ge, Chengli Dou, Wei Shen, Xifeng Zhang (*), Hong Chen (*)Impact of diethylhexyl phthalate on gene expression and development of mammary glands of pregnant mouse. Histochemistry Cell Biology, 2015 Oct, 144(4): 389-402
 
Xunsi Qin (#), Mingjun Cao (#), Fangnong Lai, Fan Yang, Wei Ge, Xifeng Zhang, Shunfeng Cheng, Xiaofeng Sun, Guoqing Qin, Wei Shen, Lan Li (*), Oxidative stress induced by zearalenone in porcine granulosa cells and its rescue by curcumin in vitro. PLoS One, 2015 Jun 1, 10(6): e0127551

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